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Pavlovian–to–Instrumental Transfer

Description: In PIT there are two stages of training, a Pavlovian stage and a instrumental stage. In the Pavlovian stage, mice are placed in the operant chambers and are presented with two discriminative cues. One cue is paired with sucrose reward (CS+) and a second cue is paired with no outcome (CS-). The mouse learns to approach the magazine recess (where the sucrose is delivered) during presentation of the CS+. In the instrumental phase, mice are placed in the operant chambers, and presented with two levers. Responding on one (active lever) lever results in the presentation of the sucrose reward and responding on a second lever has no consequence; mice quickly learn to respond on the active lever. Finally, on completion of training, a test stage is carried out where mice are placed in the operant chambers, with both levers present. During this stage, the CS+ and CS- are presented to the mice, and the degree of responding during the cues is assessed. No rewards are delivered. Typically, rodents augment responding to the active lever during the CS+ compared to the CS-, or during a period of no stimulus presentation.

Purpose: This task is designed to assess the impact of a reward associated cue to induce an increase in general arousal resulting in increased instrumental responding Targeted Neural System — CeN-VTA-Acc(core)

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